Gria1 | glutamate receptor, ionotropic, AMPA1 (alpha 1)

GeneMGI:95808Synonyms: Glur1, Glr1, +8 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Behavior/neurological Skeleton

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:

Life Stage:



hyperactivity	7 supporting datasets	Gria1^{em1(IMPC)Hmgu}	homozygote	Early adult	7.36x10^-11
hyperactivity	9 supporting datasets	Gria1^em1(IMPC)H	homozygote	Late adult	2.22x10^-43
hyperactivity	10 supporting datasets	Gria1^em1(IMPC)H	homozygote	Early adult	5.73x10^-134
impaired cued conditioning behavior	1 supporting dataset	Gria1^em1(IMPC)H	homozygote	Late adult	4.89x10^-7
abnormal locomotor behavior	1 supporting dataset	Gria1^em1(IMPC)H	homozygote	Early adult	6.41x10^-11
abnormal gait	1 supporting dataset	Gria1^em1(IMPC)H	homozygote	Late adult	2.25x10^-10
decreased freezing behavior	2 supporting datasets	Gria1^em1(IMPC)H	homozygote	Late adult	7.98x10^-9
decreased exploration in new environment	1 supporting dataset	Gria1^em1(IMPC)H	homozygote	Late adult	8.92x10^-7
increased circulating iron level	1 supporting dataset	Gria1^em1(IMPC)H	homozygote	Late adult	5.5x10^-7
increased circulating amylase level	1 supporting dataset	Gria1^{em1(IMPC)Hmgu}	homozygote	Early adult	6.18x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

** Significant with a threshold of 1x10^-3, check the Pain Sensitivity page for more information.

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* This parameter was manually assessed for significance.

** Significant with a threshold of 1x10^-3, check the Pain Sensitivity page for more information.

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lacZ Expression

No adult expression data available for Gria1.

Associated images

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Histopathology

There is no histopathology data found for Gria1.

IMPC related publications

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External links

No external links available for Gria1.

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*Gria1^em1(IMPC)H*	Exon Deletion	‌	mouse
*Gria1^{em1(IMPC)Hmgu}*	Intra-exon deletion	‌	mouse

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