Gnb2 | guanine nucleotide binding protein (G protein), beta 2

GeneMGI:95784

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina morphology	1 supporting dataset	Gnb2^em1(IMPC)J	homozygote	Early adult	1.79x10^-5
hyperactivity	10 supporting datasets	Gnb2^em1(IMPC)J	homozygote	Early adult	0
decreased circulating total protein level	1 supporting dataset	Gnb2^em1(IMPC)J	homozygote	Early adult	6.22x10^-7
increased heart rate	1 supporting dataset	Gnb2^em1(IMPC)J	homozygote	Early adult	5.81x10^-8
decreased blood urea nitrogen level	1 supporting dataset	Gnb2^em1(IMPC)J	homozygote	Early adult	1.58x10^-6
decreased thigmotaxis	4 supporting datasets	Gnb2^em1(IMPC)J	homozygote	Early adult	1.34x10^-7
increased vertical activity	1 supporting dataset	Gnb2^em1(IMPC)J	homozygote	Early adult	2.07x10^-14
increased leukocyte cell number	1 supporting dataset	Gnb2^em1(IMPC)J	homozygote	Early adult	2.98x10^-34
decreased circulating serum albumin level	1 supporting dataset	Gnb2^em1(IMPC)J	homozygote	Early adult	3.38x10^-5
decreased grip strength	4 supporting datasets	Gnb2^em1(IMPC)J	homozygote	Early adult	2.91x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gnb2.

Associated images

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Histopathology

There is no histopathology data found for Gnb2.

IMPC related publications

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External links

No external links available for Gnb2.

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*Gnb2^em1(IMPC)J*	Exon Deletion	‌	mouse
*Gnb2^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Gnb2^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell

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