Gnao1 | guanine nucleotide binding protein, alpha O

GeneMGI:95775Synonyms: Galphao, Go alpha, +1 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Skeleton Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

4Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased blood urea nitrogen level	1 supporting dataset	Gnao1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.59x10^-5
hyperactivity	7 supporting datasets	Gnao1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.33x10^-6
decreased circulating serum albumin level	1 supporting dataset	Gnao1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.88x10^-5
decreased red blood cell distribution width	1 supporting dataset	Gnao1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.88x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Gnao1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased fasting circulating glucose level	1 supporting dataset	Gnao1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.36x10^-12
decreased erythrocyte cell number	1 supporting dataset	Gnao1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.03x10^-5
abnormal bone structure	1 supporting dataset	Gnao1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.04x10^-6
increased circulating amylase level	1 supporting dataset	Gnao1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.22x10^-9
increased circulating creatinine level	1 supporting dataset	Gnao1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.53x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Gnao1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Gnao1.

IMPC related publications

Loading...

External links

No external links available for Gnao1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Gnao1^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Gnao1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gnao1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gnao1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Gnao1^{tm2(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse

My Genes