Gnl1 | guanine nucleotide binding protein-like 1

GeneMGI:95764Synonyms: Gna-rs1, Gnal1

Physiological systems

17 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton Craniofacial Cardiovascular system

6 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	2 supporting datasets	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	4.79x10^-5
abnormal bone structure	1 supporting dataset	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	1.6x10^-6
limb grasping	1 supporting dataset	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	2.42x10^-6
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	1.33x10^-5
abnormal cranium morphology	1 supporting dataset	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	1.37x10^-9
decreased lean body mass	2 supporting datasets	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	6.72x10^-9
increased vertical activity	1 supporting dataset	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	6.69x10^-5
shortened PR interval	1 supporting dataset	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	1.57x10^-5
hydrocephaly	1 supporting dataset	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased hemoglobin content	1 supporting dataset	Gnl1^em1(IMPC)Tcp	homozygote	Early adult	3.16x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gnl1.

Associated images

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Histopathology

There is no histopathology data found for Gnl1.

IMPC related publications

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External links

No external links available for Gnl1.

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*Gnl1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Gnl1^{tm79297(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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