Gpr83 | G protein-coupled receptor 83

GeneMGI:95712Synonyms: RP39, GIR, +5 more

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Liver/biliary system Hematopoietic system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal thymus morphology	2 supporting datasets	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	2 supporting datasets	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
impaired glucose tolerance	2 supporting datasets	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.33x10^-7
decreased memory-marker CD4-positive NK T cell number	1 supporting dataset	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	8.2x10^-5
decreased CD4-positive NK T cell number	1 supporting dataset	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.92x10^-5
abnormal liver morphology	1 supporting dataset	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased body weight	1 supporting dataset	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.83x10^-5
decreased NK T cell number	1 supporting dataset	Gpr83^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.33x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gpr83.

Associated images

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Histopathology

There is no histopathology data found for Gpr83.

IMPC related publications

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External links

No external links available for Gpr83.

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*Gpr83^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Gpr83^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Gpr83^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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