Ghrhr | growth hormone releasing hormone receptor

GeneMGI:95710Synonyms: Ghrfr

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

9 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

2Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased body length	1 supporting dataset	Ghrhr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.17x10^-90
decreased lean body mass	2 supporting datasets	Ghrhr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.11x10^-10
decreased bone mineral content	2 supporting datasets	Ghrhr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.35x10^-28
decreased bone mineral density	1 supporting dataset	Ghrhr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.02x10^-17
decreased mean corpuscular hemoglobin	1 supporting dataset	Ghrhr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.31x10^-5
abnormal sleep behavior	5 supporting datasets	Ghrhr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.65x10^-16
decreased heart weight	1 supporting dataset	Ghrhr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.63x10^-8
increased circulating triglyceride level	1 supporting dataset	Ghrhr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.87x10^-5
increased total body fat amount	2 supporting datasets	Ghrhr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.29x10^-12
increased circulating alanine transaminase level	1 supporting dataset	Ghrhr^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	3.19x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ghrhr.

Associated images

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Histopathology

There is no histopathology data found for Ghrhr.

IMPC related publications

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External links

No external links available for Ghrhr.

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*Ghrhr^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Ghrhr^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Ghrhr^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ghrhr^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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