Gdf6 | growth differentiation factor 6

GeneMGI:95689Synonyms: BMP13

Physiological systems

24 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

13 No significant impact

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

8Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged thymus	1 supporting dataset	Gdf6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
no spontaneous movement	1 supporting dataset	Gdf6^{em1(IMPC)Ccpcz}	homozygote	E18.5	N/A ^*
abnormal digit morphology	1 supporting dataset	Gdf6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.99x10^-8
abnormal brain morphology	1 supporting dataset	Gdf6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal optic disk morphology	1 supporting dataset	Gdf6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	8.7x10^-13
abnormal retina morphology	1 supporting dataset	Gdf6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.66x10^-8
abnormal spleen morphology	2 supporting datasets	Gdf6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Gdf6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Gdf6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased lung tissue damping	1 supporting dataset	Gdf6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	2.76x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gdf6.

Associated images

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Histopathology

There is no histopathology data found for Gdf6.

IMPC related publications

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External links

No external links available for Gdf6.

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*Gdf6^{em1(IMPC)Ccpcz}*	Inter-exon deletion	‌	mouse
*Gdf6^{tm181237(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Gdf6^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Gdf6^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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