Flt3 | FMS-like tyrosine kinase 3

GeneMGI:95559Synonyms: CD135, Flk2, +3 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Immune system Integument Growth/size/body region Limbs/digits/tail Muscle Vision/eye Hematopoietic system Cardiovascular system Renal/urinary system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

11Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal eye morphology	1 supporting dataset	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal digit morphology	1 supporting dataset	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.99x10^-8
abnormal skin morphology	2 supporting datasets	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased NK cell number	1 supporting dataset	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.26x10^-5
hydrometra	1 supporting dataset	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skeletal muscle morphology	1 supporting dataset	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased effector memory T-helper cell number	1 supporting dataset	Flt3^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.15x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Flt3.

Associated images

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Histopathology

There is no histopathology data found for Flt3.

IMPC related publications

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External links

No external links available for Flt3.

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*Flt3^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Flt3^{tm39958(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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