Fkbp4 | FK506 binding protein 4

GeneMGI:95543Synonyms: FKBP52, FKBP-52

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Embryo Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:29Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



male infertility	1 supporting dataset	Fkbp4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal cholesterol homeostasis	1 supporting dataset	Fkbp4^em1(IMPC)Mbp	homozygote	Early adult	2.47x10^-6
small seminal vesicle	1 supporting dataset	Fkbp4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased mean corpuscular volume	1 supporting dataset	Fkbp4^em1(IMPC)Mbp	homozygote	Early adult	1.91x10^-5
enlarged epididymis	1 supporting dataset	Fkbp4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small epididymis	1 supporting dataset	Fkbp4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal male genitalia morphology	2 supporting datasets	Fkbp4^em1(IMPC)Mbp	homozygote	Early adult	1.62x10^-14
abnormal placenta morphology	1 supporting dataset	Fkbp4^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
small kidney	1 supporting dataset	Fkbp4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
no spontaneous movement	1 supporting dataset	Fkbp4^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fkbp4.

Associated images

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Histopathology

There is no histopathology data found for Fkbp4.

IMPC related publications

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External links

No external links available for Fkbp4.

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*Fkbp4^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Fkbp4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Fkbp4^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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