Fbp2 | fructose bisphosphatase 2

GeneMGI:95491Synonyms: Fbp-1, FBPase muscle

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Immune system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

1Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Fbp2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal lens morphology	3 supporting datasets	Fbp2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.39x10^-6
abnormal retina blood vessel morphology	1 supporting dataset	Fbp2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.9x10^-5
abnormal lens morphology	2 supporting datasets	Fbp2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	3.25x10^-6
abnormal retina vasculature morphology	1 supporting dataset	Fbp2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.67x10^-6
increased leukocyte cell number	1 supporting dataset	Fbp2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	8.03x10^-5
abnormal vocalization	1 supporting dataset	Fbp2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	8.33x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbp2.

Associated images

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Histopathology

There is no histopathology data found for Fbp2.

IMPC related publications

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External links

No external links available for Fbp2.

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*Fbp2^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Fbp2^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fbp2^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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