Dlx3 | distal-less homeobox 3
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Behavior/neurological Mortality/aging Cardiovascular system
16 No significant impact
2 Not tested
Data collections
Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Dlx3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal blood vessel morphology | 1 supporting dataset | Dlx3em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| increased circulating calcium level | 1 supporting dataset | Dlx3em1(IMPC)Mbp | heterozygote | Early adult | 4.51x10-5 | ||
| increased freezing behavior | 1 supporting dataset | Dlx3em1(IMPC)Mbp | heterozygote | Early adult | 1.7x10-7 | ||
| edema | 1 supporting dataset | Dlx3em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Dlx3em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Dlx3em1(IMPC)Mbp | heterozygote | Early adult | 9.19x10-7 | ||
| hemorrhage | 1 supporting dataset | Dlx3em1(IMPC)Mbp | heterozygote | E15.5 | N/A * |
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External links
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| Dlx3em1(IMPC)Mbp | Exon Deletion | | mouse |
| Dlx3tm69(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |