Dcaf8 | DDB1 and CUL4 associated factor 8

GeneMGI:91860Synonyms: H326, D1Ucla4, +2 more

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Respiratory system Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal heart morphology	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased lung compliance	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.38x10^-6
abnormal retina morphology	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.5x10^-8
enlarged heart	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased lung elastance	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.09x10^-5
increased circulating potassium level	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.49x10^-6
increased blood urea nitrogen level	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.84x10^-5
increased freezing behavior	1 supporting dataset	Dcaf8^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.88x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dcaf8.

Associated images

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Histopathology

There is no histopathology data found for Dcaf8.

IMPC related publications

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External links

No external links available for Dcaf8.

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*Dcaf8^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Dcaf8^{tm300381(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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