Bach2 | BTB and CNC homology, basic leucine zipper transcription factor 2

GeneMGI:894679Synonyms: E030004N02Rik

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Limbs/digits/tail Nervous system Vision/eye Respiratory system Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:65Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased monocyte cell number	3 supporting datasets	Bach2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased Ly6C high monocyte number	1 supporting dataset	Bach2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased prepulse inhibition	5 supporting datasets	Bach2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.04x10^-8
increased Ly6C low monocyte number	1 supporting dataset	Bach2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased B cell number	1 supporting dataset	Bach2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.53x10^-11
increased memory-marker NK cell number	4 supporting datasets	Bach2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number	4 supporting datasets	Bach2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1+ CD8 alpha-beta T cell number	6 supporting datasets	Bach2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1+ CD4 alpha-beta T cell number	4 supporting datasets	Bach2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number	8 supporting datasets	Bach2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bach2.

Associated images

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Histopathology

There is no histopathology data found for Bach2.

IMPC related publications

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External links

No external links available for Bach2.

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*Bach2^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Bach2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Bach2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Bach2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Bach2^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse

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