Hlcs | holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Behavior/neurological Mortality/aging
13 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Hlcsem1(IMPC)J | homozygote | Early adult | N/A * | ||
| abnormal locomotor behavior | 1 supporting dataset | Hlcsem1(IMPC)J | heterozygote | Late adult | 2.06x10-5 | ||
| decreased circulating calcium level | 1 supporting dataset | Hlcsem1(IMPC)J | heterozygote | Early adult | 5.11x10-9 | ||
| decreased circulating phosphate level | 1 supporting dataset | Hlcsem1(IMPC)J | heterozygote | Early adult | 7.71x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Hlcsem1(IMPC)J | heterozygote | Late adult | 2.12x10-5 | ||
| abnormal coat/hair pigmentation | 1 supporting dataset | Hlcsem1(IMPC)J | heterozygote | Late adult | 5.34x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Hlcsem1(IMPC)J | homozygote | E9.5 | N/A * |
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External links
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| Hlcsem1(IMPC)J | Exon Deletion | | mouse |