Gngt2 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Skeleton Cardiovascular system Mortality/aging

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral content	2 supporting datasets	Gngt2^em1(IMPC)Bay	homozygote	Early adult	3.64x10^-5
increased spleen weight	1 supporting dataset	Gngt2^em1(IMPC)Bay	homozygote	Early adult	3.1x10^-16
decreased total retina thickness	2 supporting datasets	Gngt2^em1(IMPC)Bay	homozygote	Early adult	1.97x10^-9
increased lean body mass	2 supporting datasets	Gngt2^em1(IMPC)Bay	homozygote	Early adult	7.68x10^-6
abnormal retina outer nuclear layer morphology	2 supporting datasets	Gngt2^em1(IMPC)Bay	homozygote	Early adult	2.47x10^-6
increased fasting circulating glucose level	1 supporting dataset	Gngt2^em1(IMPC)Bay	homozygote	Early adult	1.67x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Gngt2^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
increased heart left ventricle size	1 supporting dataset	Gngt2^em1(IMPC)Bay	homozygote	Early adult	6.33x10^-7
decreased total body fat amount	2 supporting datasets	Gngt2^em1(IMPC)Bay	homozygote	Early adult	1.25x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gngt2.

Associated images

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Histopathology

There is no histopathology data found for Gngt2.

IMPC related publications

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External links

No external links available for Gngt2.

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*Gngt2^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Gngt2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Gngt2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gngt2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Gngt2^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse

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