Plscr1 | phospholipid scramblase 1

GeneMGI:893575Synonyms: TRA1, MmTRA1a, +5 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Vision/eye Behavior/neurological Cardiovascular system

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal retina outer nuclear layer morphology2 supporting datasetsPlscr1tm1b(EUCOMM)HmguhomozygoteEarly adult2.28x10-8 
increased startle reflex1 supporting datasetPlscr1tm1b(EUCOMM)HmguhomozygoteEarly adult6.02x10-5 
decreased total retina thickness2 supporting datasetsPlscr1tm1b(EUCOMM)HmguhomozygoteEarly adult8.16x10-14 
shortened QRS complex duration1 supporting datasetPlscr1tm1b(EUCOMM)HmguhomozygoteEarly adult4.37x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Plscr1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Plscr1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Plscr1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse

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