Dgcr2 | DiGeorge syndrome critical region gene 2

GeneMGI:892866Synonyms: Dgcr2, Idd, +5 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hematopoietic system Skeleton

13 No significant impact

7 Not tested

Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
0Embryo tissues

Phenotypes

abnormal spleen morphology1 supporting datasetDgcr2tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
impaired glucose tolerance1 supporting datasetDgcr2tm1b(EUCOMM)WtsihomozygoteEarly adult6.63x10-5 
increased bone mineral content1 supporting datasetDgcr2tm1b(EUCOMM)WtsihomozygoteEarly adult5.28x10-6 
abnormal pelvic girdle bone morphology1 supporting datasetDgcr2tm1b(EUCOMM)WtsihomozygoteEarly adult2.03x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dgcr2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Dgcr2tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Dgcr2tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Dgcr2tm46920(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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