Cyp27a1 | cytochrome P450, family 27, subfamily a, polypeptide 1

GeneMGI:88594Synonyms: cholesterol 27 hydroxylase, 1300013A03Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Liver/biliary system Hematopoietic system Cardiovascular system

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating triglyceride level	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.23x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.78x10^-18
improved glucose tolerance	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.41x10^-5
decreased mean platelet volume	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.9x10^-5
decreased circulating serum albumin level	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.85x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.31x10^-5
increased liver weight	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	0
shortened QRS complex duration	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.71x10^-5
increased lean body mass	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.15x10^-5
prolonged RR interval	1 supporting dataset	Cyp27a1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.17x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cyp27a1.

Associated images

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Histopathology

There is no histopathology data found for Cyp27a1.

IMPC related publications

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External links

No external links available for Cyp27a1.

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*Cyp27a1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Cyp27a1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Cyp27a1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cyp27a1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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