Cox5b | cytochrome c oxidase subunit 5B

GeneMGI:88475

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Integument Limbs/digits/tail Vision/eye Liver/biliary system Behavior/neurological Mortality/aging

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin coloration	1 supporting dataset	Cox5b^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	8.89x10^-7
unresponsive to tactile stimuli	1 supporting dataset	Cox5b^{tm2b(EUCOMM)Hmgu}	heterozygote	E18.5	N/A ^*
abnormal liver size	1 supporting dataset	Cox5b^{tm2b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
pallor	1 supporting dataset	Cox5b^{tm2b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
abnormal embryonic autopod plate morphology	1 supporting dataset	Cox5b^{tm2b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Cox5b^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.02x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Cox5b^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Cox5b^{tm2b(EUCOMM)Hmgu}	homozygote	E15.5	N/A ^*
pale liver	1 supporting dataset	Cox5b^{tm2b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cox5b.

Associated images

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Histopathology

There is no histopathology data found for Cox5b.

IMPC related publications

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External links

No external links available for Cox5b.

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*Cox5b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cox5b^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cox5b^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cox5b^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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