Ckb | creatine kinase, brain

GeneMGI:88407Synonyms: B-CK, Ck-3

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Immune system Integument Adipose tissue Growth/size/body region Nervous system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased exploration in new environment	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	2.62x10^-5
increased mean corpuscular volume	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	3.43x10^-15
increased lymphocyte cell number	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	8x10^-5
abnormal auditory brainstem response	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	3.27x10^-5
decreased brain weight	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	4.29x10^-5
decreased total body fat amount	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.32x10^-6
increased bone mineral content	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	4.42x10^-8
abnormal vibrissa morphology	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.15x10^-7
decreased prepulse inhibition	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.12x10^-6
increased mean corpuscular hemoglobin	1 supporting dataset	Ckb^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.77x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ckb.

Associated images

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Histopathology

There is no histopathology data found for Ckb.

IMPC related publications

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External links

No external links available for Ckb.

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*Ckb^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Ckb^{tm1.1(KOMP)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Ckb^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ckb^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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