Btg1 | BTG anti-proliferation factor 1

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Cardiovascular system Renal/urinary system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal ovary morphology	1 supporting dataset	Btg1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Btg1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Btg1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged ovary	1 supporting dataset	Btg1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased lymphocyte cell number	1 supporting dataset	Btg1^em1(IMPC)Mbp	homozygote	Early adult	4.24x10^-7
increased eosinophil cell number	2 supporting datasets	Btg1^em1(IMPC)Mbp	homozygote	Early adult	2.5x10^-6
increased heart weight	2 supporting datasets	Btg1^em1(IMPC)Mbp	homozygote	Early adult	6.54x10^-6
enlarged uterus	1 supporting dataset	Btg1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	2 supporting datasets	Btg1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Btg1^em1(IMPC)Mbp	homozygote	Early adult	2.88x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Btg1.

Associated images

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Histopathology

There is no histopathology data found for Btg1.

IMPC related publications

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External links

No external links available for Btg1.

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*Btg1^em1(IMPC)Mbp*	Whole-gene deletion	‌	mouse
*Btg1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Btg1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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