Bmp4 | bone morphogenetic protein 4

GeneMGI:88180Synonyms: Bmp2b, Bmp2b-1, +2 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:24Significant phenotypes

6Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased anxiety-related response	1 supporting dataset	Bmp4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.92x10^-7
hyperactivity	8 supporting datasets	Bmp4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.66x10^-39
abnormal hindbrain development	1 supporting dataset	Bmp4^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
decreased total retina thickness	1 supporting dataset	Bmp4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.8x10^-5
abnormal retina outer nuclear layer morphology	1 supporting dataset	Bmp4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.55x10^-11
eyelids fail to open	1 supporting dataset	Bmp4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.89x10^-6
increased grip strength	1 supporting dataset	Bmp4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.87x10^-5
abnormal embryo development	1 supporting dataset	Bmp4^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal embryo size	1 supporting dataset	Bmp4^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
microphthalmia	1 supporting dataset	Bmp4^{tm1b(EUCOMM)Hmgu}	heterozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bmp4.

Associated images

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Histopathology

There is no histopathology data found for Bmp4.

IMPC related publications

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External links

No external links available for Bmp4.

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*Bmp4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Bmp4^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Bmp4^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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