Atf4 | activating transcription factor 4
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Nervous system Hematopoietic system Mortality/aging
17 No significant impact
2 Not tested
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
51Embryo tissues
| increased circulating alanine transaminase level | 1 supporting dataset | Atf4tm1(KOMP)Mbp | heterozygote | Early adult | 4.33x10-6 | ||
| decreased monocyte cell number | 1 supporting dataset | Atf4tm1(KOMP)Mbp | heterozygote | Early adult | 2.05x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Atf4tm1(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Atf4tm1(KOMP)Mbp | heterozygote | Early adult | 3.53x10-7 | ||
| decreased prepulse inhibition | 1 supporting dataset | Atf4tm1(KOMP)Mbp | heterozygote | Early adult | 4.74x10-5 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Atf4tm1(KOMP)Mbp | heterozygote | Early adult | 1.68x10-5 |
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External links
No external links available for Atf4.
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