Alox5 | arachidonate 5-lipoxygenase

GeneMGI:87999Synonyms: 5-LOX, 5LX, +1 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Growth/size/body region Hematopoietic system Skeleton

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	1 supporting dataset	Alox5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thoracic cage shape	1 supporting dataset	Alox5^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.52x10^-5
enlarged spleen	1 supporting dataset	Alox5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Alox5.

Associated images

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Histopathology

There is no histopathology data found for Alox5.

IMPC related publications

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External links

No external links available for Alox5.

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*Alox5^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Alox5^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Alox5^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Alox5^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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