Alas1 | aminolevulinic acid synthase 1

GeneMGI:87989Synonyms: 5-aminolevulinate synthase, succinyl-CoA: glycine C-succinyl transferase, +2 more

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Growth/size/body region Vision/eye Mortality/aging Cardiovascular system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



cataract	1 supporting dataset	Alas1^em1(IMPC)Mbp	heterozygote	Early adult	6.35x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Alas1^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Alas1^em1(IMPC)Mbp	heterozygote	Early adult	5.99x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Alas1^em1(IMPC)Mbp	heterozygote	Early adult	5.96x10^-11
preweaning lethality, complete penetrance	3 supporting datasets	Alas1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Alas1^em1(IMPC)Mbp	heterozygote	Early adult	3.62x10^-9
enlarged ovary	1 supporting dataset	Alas1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal ovary morphology	1 supporting dataset	Alas1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Alas1.

Associated images

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Histopathology

There is no histopathology data found for Alas1.

IMPC related publications

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External links

No external links available for Alas1.

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*Alas1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Alas1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Alas1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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