Aco2 | aconitase 2, mitochondrial

GeneMGI:87880Synonyms: D10Wsu183e, Aco-2, +2 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



decreased body weight	1 supporting dataset	Aco2^{Gt(EUC0050e03)Hmgu}	heterozygote	Early adult	3.4x10^-5
decreased IgM level	1 supporting dataset	Aco2^{Gt(EUC0050e03)Hmgu}	heterozygote	Early adult	2.39x10^-7
increased circulating cholesterol level	1 supporting dataset	Aco2^{Gt(EUC0050e03)Hmgu}	heterozygote	Early adult	5.9x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Aco2^em1(IMPC)J	homozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Aco2^{Gt(EUC0050e03)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating amylase level	1 supporting dataset	Aco2^{Gt(EUC0050e03)Hmgu}	heterozygote	Early adult	1.36x10^-5
decreased IgG3 level	1 supporting dataset	Aco2^{Gt(EUC0050e03)Hmgu}	heterozygote	Early adult	9.34x10^-6
decreased IgG1 level	1 supporting dataset	Aco2^{Gt(EUC0050e03)Hmgu}	heterozygote	Early adult	9.54x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aco2.

Associated images

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Histopathology

There is no histopathology data found for Aco2.

IMPC related publications

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External links

No external links available for Aco2.

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*Aco2^em1(IMPC)J*	Exon Deletion	‌	mouse
*Aco2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Aco2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Aco2^{tm39540(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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