Sh3gl2 | SH3-domain GRB2-like 2

GeneMGI:700009Synonyms: EEN-B1, endophilin A1, +5 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological Skeleton

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral density	1 supporting dataset	Sh3gl2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.37x10^-11
increased circulating alanine transaminase level	1 supporting dataset	Sh3gl2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.35x10^-6
decreased grip strength	1 supporting dataset	Sh3gl2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.11x10^-6
decreased exploration in new environment	1 supporting dataset	Sh3gl2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.49x10^-7
increased circulating aspartate transaminase level	1 supporting dataset	Sh3gl2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.14x10^-18
decreased bone mineral content	1 supporting dataset	Sh3gl2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.84x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sh3gl2.

Associated images

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Histopathology

There is no histopathology data found for Sh3gl2.

IMPC related publications

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External links

No external links available for Sh3gl2.

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*Sh3gl2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sh3gl2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sh3gl2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Sh3gl2^{tm438(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Sh3gl2^{tm45700(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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