Dbnl | drebrin-like

GeneMGI:700006Synonyms: mAbp1, SH3P7, +1 more

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hearing/vestibular/ear Vision/eye Nervous system Hematopoietic system Behavior/neurological Cardiovascular system

9 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:24Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating glucose level	1 supporting dataset	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.57x10^-5
decreased circulating triglyceride level	1 supporting dataset	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.1x10^-5
decreased locomotor activity	4 supporting datasets	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.06x10^-7
abnormal optic disk morphology	1 supporting dataset	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.08x10^-6
abnormal retina inner nuclear layer morphology	2 supporting datasets	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.7x10^-5
persistence of hyaloid vascular system	1 supporting dataset	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.7x10^-10
decreased circulating alkaline phosphatase level	1 supporting dataset	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.66x10^-12
abnormal auditory brainstem response	2 supporting datasets	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.69x10^-7
increased fluid intake	1 supporting dataset	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.23x10^-6
abnormal retina blood vessel morphology	1 supporting dataset	Dbnl^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.34x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dbnl.

Associated images

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Histopathology

There is no histopathology data found for Dbnl.

IMPC related publications

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External links

No external links available for Dbnl.

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*Dbnl^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Dbnl^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dbnl^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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