Mthfsl | 5, 10-methenyltetrahydrofolate synthetase-like

GeneMGI:3780550Synonyms: Gm2382

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Vision/eye Behavior/neurological

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

2Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



cataract	1 supporting dataset	Mthfsl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.22x10^-7
abnormal lens morphology	1 supporting dataset	Mthfsl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.27x10^-7
decreased grip strength	1 supporting dataset	Mthfsl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.88x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mthfsl.

Associated images

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Histopathology

There is no histopathology data found for Mthfsl.

IMPC related publications

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External links

No external links available for Mthfsl.

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*Mthfsl^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Mthfsl^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mthfsl^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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