Aadacl4 | arylacetamide deacetylase like 4

GeneMGI:3650257Synonyms: Gm13177

Physiological systems

21 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Endocrine/exocrine gland Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

10 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased mean corpuscular volume	1 supporting dataset	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.85x10^-11
abnormal retina vasculature morphology	1 supporting dataset	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	8.43x10^-5
abnormal spleen morphology	2 supporting datasets	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased lean body mass	2 supporting datasets	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.86x10^-7
enhanced contextual conditioning behavior	1 supporting dataset	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.91x10^-13
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.55x10^-10
enlarged thymus	1 supporting dataset	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased circulating sodium level	1 supporting dataset	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.84x10^-6
increased kidney weight	1 supporting dataset	Aadacl4^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.27x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aadacl4.

Associated images

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Histopathology

There is no histopathology data found for Aadacl4.

IMPC related publications

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External links

No external links available for Aadacl4.

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*Aadacl4^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Aadacl4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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