Spink14 | serine peptidase inhibitor, Kazal type 14

GeneMGI:3646952Synonyms: Gm5505

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Growth/size/body region Hematopoietic system Skeleton

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased anti-nuclear antigen antibody level	4 supporting datasets	Spink14^{tm1e(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased immature NK cell number	1 supporting dataset	Spink14^{tm1e(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased macrophage cell number	1 supporting dataset	Spink14^{tm1e(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased lean body mass	1 supporting dataset	Spink14^{tm1e(KOMP)Wtsi}	homozygote	Early adult	1.99x10^-5
decreased NK cell number	1 supporting dataset	Spink14^{tm1e(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased memory-marker NK cell number	1 supporting dataset	Spink14^{tm1e(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased mature NK cell number	1 supporting dataset	Spink14^{tm1e(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral density	1 supporting dataset	Spink14^{tm1e(KOMP)Wtsi}	homozygote	Early adult	3.59x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Spink14.

Associated images

Loading...

Histopathology

There is no histopathology data found for Spink14.

IMPC related publications

Loading...

External links

No external links available for Spink14.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Spink14^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Spink14^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell mouse

My Genes