Shank1 | SH3 and multiple ankyrin repeat domains 1

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Integument Growth/size/body region Vision/eye Liver/biliary system Behavior/neurological

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased exploration in new environment	1 supporting dataset	Shank1^em1(IMPC)Mbp	homozygote	Late adult	6.15x10^-14
increased grip strength	2 supporting datasets	Shank1^em1(IMPC)Mbp	homozygote	Middle aged adult	1.04x10^-9
abnormal skin morphology	2 supporting datasets	Shank1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
decreased locomotor activity	5 supporting datasets	Shank1^em1(IMPC)Mbp	homozygote	Early adult	1.64x10^-6
abnormal gait	1 supporting dataset	Shank1^em1(IMPC)Mbp	homozygote	Late adult	5.34x10^-5
small liver	1 supporting dataset	Shank1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Shank1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged gallbladder	1 supporting dataset	Shank1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Shank1^em1(IMPC)Mbp	homozygote	Early adult	7.3x10^-5
cataract	1 supporting dataset	Shank1^em1(IMPC)Mbp	homozygote	Early adult	9.23x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Shank1.

Associated images

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Histopathology

There is no histopathology data found for Shank1.

IMPC related publications

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External links

No external links available for Shank1.

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*Shank1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Shank1^{tm39541(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes