Tmem145 | transmembrane protein 145

GeneMGI:3607779Synonyms: B930076A02Rik

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Nervous system Vision/eye Behavior/neurological Cardiovascular system Renal/urinary system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	6 supporting datasets	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	1.83x10^-6
eye hemorrhage	1 supporting dataset	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	2.1x10^-5
cataract	1 supporting dataset	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	6.35x10^-5
decreased startle reflex	1 supporting dataset	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	1.13x10^-5
abnormal kidney morphology	1 supporting dataset	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	1.96x10^-7
abnormal vitreous body morphology	1 supporting dataset	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	5.99x10^-5
abnormal retina morphology	1 supporting dataset	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	5.3x10^-5
decreased prepulse inhibition	1 supporting dataset	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	1.42x10^-6
small kidney	1 supporting dataset	Tmem145^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmem145.

Associated images

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Histopathology

There is no histopathology data found for Tmem145.

IMPC related publications

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External links

No external links available for Tmem145.

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*Tmem145^em1(IMPC)Mbp*	Intra-exon deletion	‌	mouse
*Tmem145^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tmem145^{tm459065(L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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