Prdm14 | PR domain containing 14

Physiological systems

19 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging

8 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



abnormal bone structure	1 supporting dataset	Prdm14^em1(IMPC)Bay	homozygote	Early adult	3.99x10^-5
decreased lean body mass	2 supporting datasets	Prdm14^em1(IMPC)Bay	homozygote	Early adult	1.43x10^-7
female infertility	1 supporting dataset	Prdm14^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased bone mineral content	2 supporting datasets	Prdm14^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.19x10^-18
decreased lean body mass	1 supporting dataset	Prdm14^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.75x10^-5
abnormal eye anterior chamber depth	1 supporting dataset	Prdm14^em1(IMPC)Bay	homozygote	Early adult	7.94x10^-9
abnormal bone structure	1 supporting dataset	Prdm14^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.26x10^-7
decreased bone mineral content	2 supporting datasets	Prdm14^em1(IMPC)Bay	homozygote	Early adult	1.75x10^-11
short tibia	1 supporting dataset	Prdm14^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.46x10^-9
male infertility	1 supporting dataset	Prdm14^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prdm14.

Associated images

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Histopathology

There is no histopathology data found for Prdm14.

IMPC related publications

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External links

No external links available for Prdm14.

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*Prdm14^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Prdm14^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Prdm14^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Prdm14^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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