Dok7 | docking protein 7

GeneMGI:3584043Synonyms: Dok-7, A930013K19Rik, +2 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Growth/size/body region Hearing/vestibular/ear Hematopoietic system Mortality/aging

17 No significant impact

2 Not tested

Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:41Adult tissues
29Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsDok7tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal auditory brainstem response1 supporting datasetDok7tm1.1(KOMP)VlcgheterozygoteEarly adult6.42x10-5 
decreased lymphocyte cell number1 supporting datasetDok7tm1.1(KOMP)VlcgheterozygoteEarly adult8.26x10-5 
increased neutrophil cell number1 supporting datasetDok7tm1.1(KOMP)VlcgheterozygoteEarly adult6.28x10-6 
decreased body length1 supporting datasetDok7tm1.1(KOMP)VlcgheterozygoteEarly adult2.88x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dok7tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Dok7tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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