Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | N/A | hemizygote | 0.0% (0 of 1) |
Adrenal gland | N/A | heterozygote | 0.0% (0 of 1) |
Aorta | N/A | hemizygote | 0.0% (0 of 1) |
Aorta | N/A | heterozygote | 0.0% (0 of 1) |
Blood vessel | N/A | hemizygote | 0.0% (0 of 1) |
Blood vessel | N/A | heterozygote | 0.0% (0 of 1) |
Bone | N/A | hemizygote | 0.0% (0 of 1) |
Bone | N/A | heterozygote | 0.0% (0 of 1) |
Brain | N/A | hemizygote | 100% (1 of 1) |
Brain | N/A | heterozygote | 100% (1 of 1) |
Brainstem | N/A | hemizygote | 0.0% (0 of 1) |
Brainstem | N/A | heterozygote | 0.0% (0 of 1) |
Brown adipose tissue | N/A | hemizygote | 0.0% (0 of 1) |
Brown adipose tissue | N/A | heterozygote | Not available |
Cartilage tissue | N/A | hemizygote | 0.0% (0 of 1) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 1) |
Cerebellum | N/A | hemizygote | 0.0% (0 of 1) |
Cerebellum | N/A | heterozygote | 0.0% (0 of 1) |
Cerebral cortex | N/A | hemizygote | 0.0% (0 of 1) |
Cerebral cortex | N/A | heterozygote | 0.0% (0 of 1) |
Eye | N/A | hemizygote | 0.0% (0 of 1) |
Eye | N/A | heterozygote | 0.0% (0 of 1) |
Gall bladder | N/A | hemizygote | 0.0% (0 of 1) |
Gall bladder | N/A | heterozygote | 0.0% (0 of 1) |
Heart | N/A | hemizygote | 0.0% (0 of 1) |
Heart | N/A | heterozygote | 0.0% (0 of 1) |
Hippocampus | N/A | hemizygote | 100% (1 of 1) |
Hippocampus | N/A | heterozygote | 100% (1 of 1) |
Hypothalamus | N/A | hemizygote | 100% (1 of 1) |
Hypothalamus | N/A | heterozygote | 100% (1 of 1) |
Kidney | N/A | hemizygote | 0.0% (0 of 1) |
Kidney | N/A | heterozygote | 0.0% (0 of 1) |
Large intestine | N/A | hemizygote | 0.0% (0 of 1) |
Large intestine | N/A | heterozygote | 0.0% (0 of 1) |
Liver | N/A | hemizygote | 0.0% (0 of 1) |
Liver | N/A | heterozygote | 0.0% (0 of 1) |
Lower urinary tract | N/A | hemizygote | 0.0% (0 of 1) |
Lower urinary tract | N/A | heterozygote | 100% (1 of 1) |
Lung | N/A | hemizygote | 0.0% (0 of 1) |
Lung | N/A | heterozygote | 0.0% (0 of 1) |
Lymph node | N/A | hemizygote | 0.0% (0 of 1) |
Lymph node | N/A | heterozygote | 0.0% (0 of 1) |
Mammary gland | N/A | hemizygote | 0.0% (0 of 1) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 1) |
Esophagus | N/A | hemizygote | 0.0% (0 of 1) |
Esophagus | N/A | heterozygote | 0.0% (0 of 1) |
Olfactory lobe | N/A | hemizygote | 100% (1 of 1) |
Olfactory lobe | N/A | heterozygote | 100% (1 of 1) |
Ovary | N/A | hemizygote | Not available |
Ovary | N/A | heterozygote | 0.0% (0 of 1) |
Oviduct | N/A | hemizygote | Not available |
Oviduct | N/A | heterozygote | 0.0% (0 of 1) |
Pancreas | N/A | hemizygote | 0.0% (0 of 1) |
Pancreas | N/A | heterozygote | 0.0% (0 of 1) |
Parathyroid gland | N/A | hemizygote | 0.0% (0 of 1) |
Parathyroid gland | N/A | heterozygote | 0.0% (0 of 1) |
Peripheral nervous system | N/A | hemizygote | 0.0% (0 of 1) |
Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 1) |
Peyer's patch | N/A | hemizygote | 0.0% (0 of 1) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 1) |
Pituitary gland | N/A | hemizygote | 0.0% (0 of 1) |
Pituitary gland | N/A | heterozygote | 0.0% (0 of 1) |
Prostate gland | N/A | hemizygote | 0.0% (0 of 1) |
Prostate gland | N/A | heterozygote | Not available |
Skeletal muscle tissue | N/A | hemizygote | 0.0% (0 of 1) |
Skeletal muscle tissue | N/A | heterozygote | 0.0% (0 of 1) |
Skin | N/A | hemizygote | 100% (1 of 1) |
Skin | N/A | heterozygote | 100% (1 of 1) |
Small intestine | N/A | hemizygote | 0.0% (0 of 1) |
Small intestine | N/A | heterozygote | 0.0% (0 of 1) |
Spinal cord | N/A | hemizygote | 0.0% (0 of 1) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 1) |
Spleen | N/A | hemizygote | 0.0% (0 of 1) |
Spleen | N/A | heterozygote | 0.0% (0 of 1) |
Stomach | N/A | hemizygote | 0.0% (0 of 1) |
Stomach | N/A | heterozygote | 0.0% (0 of 1) |
Striatum | N/A | hemizygote | 0.0% (0 of 1) |
Striatum | N/A | heterozygote | 0.0% (0 of 1) |
Testis | N/A | hemizygote | 100% (1 of 1) |
Testis | N/A | heterozygote | Not available |
Thymus | N/A | hemizygote | 0.0% (0 of 1) |
Thymus | N/A | heterozygote | 0.0% (0 of 1) |
Thyroid gland | N/A | hemizygote | 0.0% (0 of 1) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 1) |
Trachea | N/A | hemizygote | 0.0% (0 of 1) |
Trachea | N/A | heterozygote | 0.0% (0 of 1) |
Uterus | N/A | hemizygote | Not available |
Uterus | N/A | heterozygote | 0.0% (0 of 1) |
White adipose tissue | N/A | hemizygote | 0.0% (0 of 1) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 1) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood vessel | |
bone | 0.0% |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
heart | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
oesophagus | |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
peripheral nervous system | 0.0% |
peyer's patch | |
pituitary gland | 0.0% |
prostate gland | 0.0% |
skeletal muscle tissue | |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
striatum | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
trachea | 0.0% |
uterus | 0.0% |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Xkrx by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Complement Component 4, Partial Deficiency Of | Systemic lupus erythematosus | OMIM:120790 | |
Autoimmune Disease | Autoimmunity, Autoimmune antibody positivity | OMIM:109100 | |
Pemphigus Vulgaris, Familial | Autoimmunity, Autoimmune antibody positivity | OMIM:169610 | |
Hashimoto Thyroiditis | Hashimoto thyroiditis, Autoimmune antibody positivity | OMIM:140300 | |
Tn Polyagglutination Syndrome | Autoimmunity | OMIM:300622 | |
Systemic Lupus Erythematosus 16 | Anti-dsDNA antibody positivity, Perinuclear antineutrophil antibody positivity, Antinuclear antib... | OMIM:614420 | |
C1Q Deficiency 1 | Autoimmunity, Systemic lupus erythematosus | OMIM:613652 | |
Complement Component 2 Deficiency | Systemic lupus erythematosus | OMIM:217000 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Xkrx.
There are 5 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. | G3 (Bethesda, Md.) (June 2020) | Xkrxtm1b(EUCOMM)Wtsi | PMC7263671 |
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. | Nature immunology (December 2019) | Xkrxtm1b(EUCOMM)Wtsi | PMC7338221 |
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. | Nature communications (August 2019) | Xkrxtm1b(EUCOMM)Wtsi | PMC6671969 |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. | PLoS biology (April 2019) | Xkrxtm1b(EUCOMM)Wtsi | PMC6459510 |
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. | Scientific data (September 2017) | Xkrxtm1b(EUCOMM)Wtsi | PMC5827107 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Xkrxtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
Xkrxtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Xkrxtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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