Apcdd1 | adenomatosis polyposis coli down-regulated 1
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Integument Nervous system Vision/eye Skeleton Renal/urinary system
15 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased prepulse inhibition | 2 supporting datasets | Apcdd1em1(IMPC)Mbp | homozygote | Early adult | 2.83x10-5 | ||
| cataract | 1 supporting dataset | Apcdd1em1(IMPC)Mbp | homozygote | Early adult | 9.23x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Apcdd1em1(IMPC)Mbp | homozygote | Early adult | 2.22x10-5 | ||
| small kidney | 1 supporting dataset | Apcdd1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal vitreous body morphology | 1 supporting dataset | Apcdd1em1(IMPC)Mbp | homozygote | Early adult | 7.3x10-5 | ||
| abnormal kidney morphology | 1 supporting dataset | Apcdd1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Apcdd1em1(IMPC)Mbp | homozygote | Early adult | N/A * |
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Human diseases caused by Apcdd1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Apcdd1.
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| Apcdd1em1(IMPC)Mbp | Exon Deletion | | mouse |
| Apcdd1tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Apcdd1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Apcdd1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |