Apcdd1 | adenomatosis polyposis coli down-regulated 1

GeneMGI:3513977Synonyms: Drapc1, EIG180

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Integument Nervous system Vision/eye Skeleton Renal/urinary system

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased prepulse inhibition2 supporting datasetsApcdd1em1(IMPC)MbphomozygoteEarly adult2.83x10-5 
cataract1 supporting datasetApcdd1em1(IMPC)MbphomozygoteEarly adult9.23x10-5 
increased bone mineral content1 supporting datasetApcdd1em1(IMPC)MbphomozygoteEarly adult2.22x10-5 
small kidney1 supporting datasetApcdd1em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal vitreous body morphology1 supporting datasetApcdd1em1(IMPC)MbphomozygoteEarly adult7.3x10-5 
abnormal kidney morphology1 supporting datasetApcdd1em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal skin morphology1 supporting datasetApcdd1em1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Apcdd1em1(IMPC)MbpExon Deletionmouse
Apcdd1tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Apcdd1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Apcdd1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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