Cbx6 | chromobox 6

GeneMGI:3512628

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal tibia morphology	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.26x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.1x10^-6
increased blood urea nitrogen level	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.15x10^-19
decreased mean platelet volume	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.36x10^-5
increased circulating amylase level	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.12x10^-8
increased bone mineral content	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.83x10^-7
decreased circulating glucose level	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.56x10^-7
decreased fasting circulating glucose level	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.4x10^-7
decreased total body fat amount	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.1x10^-5
increased circulating sodium level	1 supporting dataset	Cbx6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.24x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cbx6.

Associated images

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Histopathology

There is no histopathology data found for Cbx6.

IMPC related publications

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External links

No external links available for Cbx6.

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*Cbx6^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cbx6^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cbx6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cbx6^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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