Fbxw18 | F-box and WD-40 domain protein 18

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Nervous system Hematopoietic system Skeleton Cardiovascular system Craniofacial Mortality/aging

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Fbxw18^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	2 supporting datasets	Fbxw18^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal tooth morphology	1 supporting dataset	Fbxw18^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal thymus morphology	2 supporting datasets	Fbxw18^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Fbxw18^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Fbxw18^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
hydrocephaly	1 supporting dataset	Fbxw18^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Fbxw18^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Fbxw18^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal brain morphology	1 supporting dataset	Fbxw18^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbxw18.

Associated images

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Histopathology

There is no histopathology data found for Fbxw18.

IMPC related publications

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External links

No external links available for Fbxw18.

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*Fbxw18^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse

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