Awat2 | acyl-CoA wax alcohol acyltransferase 2

GeneMGI:3045345Synonyms: 9430062J17Rik, Dgat2l4

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Vision/eye Cardiovascular system Renal/urinary system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal eye morphology	1 supporting dataset	Awat2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Awat2^em1(IMPC)Mbp	hemizygote	Early adult	N/A ^*
abnormal urinary bladder morphology	1 supporting dataset	Awat2^em1(IMPC)Mbp	hemizygote	Early adult	N/A ^*
abnormal pancreas morphology	1 supporting dataset	Awat2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
eye hemorrhage	1 supporting dataset	Awat2^em1(IMPC)Mbp	hemizygote	Early adult	5.31x10^-12
abnormal eyelid morphology	1 supporting dataset	Awat2^em1(IMPC)Mbp	hemizygote	Early adult	3.28x10^-21
abnormal lymph node morphology	1 supporting dataset	Awat2^em1(IMPC)Mbp	hemizygote	Early adult	N/A ^*
eye hemorrhage	1 supporting dataset	Awat2^em1(IMPC)Mbp	homozygote	Early adult	2.32x10^-13
increased circulating aspartate transaminase level	1 supporting dataset	Awat2^em1(IMPC)Mbp	homozygote	Early adult	9.61x10^-8
abnormal eyelid morphology	1 supporting dataset	Awat2^em1(IMPC)Mbp	homozygote	Early adult	3.67x10^-21

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Awat2.

Associated images

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Histopathology

There is no histopathology data found for Awat2.

IMPC related publications

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External links

No external links available for Awat2.

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*Awat2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Awat2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Awat2^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Awat2^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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