Arhgef15 | Rho guanine nucleotide exchange factor 15

GeneMGI:3045246Synonyms: D530030K12Rik

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Reproductive system Nervous system Hematopoietic system Mortality/aging

17 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



hydrocephaly	1 supporting dataset	Arhgef15^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal brain morphology	1 supporting dataset	Arhgef15^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Arhgef15^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Arhgef15^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.03x10^-5
male infertility	1 supporting dataset	Arhgef15^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arhgef15.

Associated images

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Histopathology

There is no histopathology data found for Arhgef15.

IMPC related publications

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External links

No external links available for Arhgef15.

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*Arhgef15^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Arhgef15^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Arhgef15^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Arhgef15^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Arhgef15^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Arhgef15^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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