Nfkbid | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta

GeneMGI:3041243Synonyms: IkappaBNS

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hematopoietic system Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased NK cell number1 supporting datasetNfkbidtm1a(EUCOMM)WtsiheterozygoteEarly adult3.89x10-5 
increased CD8-positive, alpha-beta T cell number1 supporting datasetNfkbidtm1a(EUCOMM)WtsiheterozygoteEarly adult4.61x10-6 
decreased B cell number1 supporting datasetNfkbidtm1a(EUCOMM)WtsiheterozygoteEarly adult1.05x10-5 
preweaning lethality, complete penetrance1 supporting datasetNfkbidtm1a(EUCOMM)WtsihomozygoteEarly adultN/A * 
decreased circulating triglyceride level1 supporting datasetNfkbidtm1a(EUCOMM)WtsiheterozygoteEarly adult1.52x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Nfkbidtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Nfkbidtm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Nfkbidtm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Nfkbidtm44655(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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