Palb2 | partner and localizer of BRCA2
GeneMGI:3040695
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Mortality/aging
17 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
8Associated diseases
Expression examined in:49Adult tissues
29Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Palb2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased circulating free fatty acids level | 1 supporting dataset | Palb2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 7.4x10-5 | ||
| increased circulating insulin level | 1 supporting dataset | Palb2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 8.22x10-6 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Palb2tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * |
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| Palb2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Palb2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Palb2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Palb2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Palb2tm96762(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |