Mcu | mitochondrial calcium uniporter

GeneMGI:3026965Synonyms: D130073L02Rik, 2010012O16Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Mortality/aging

14 No significant impact

5 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

increased circulating cholesterol level1 supporting datasetMcutm1b(EUCOMM)HmguheterozygoteEarly adult3.21x10-5 
decreased lean body mass2 supporting datasetsMcutm1b(EUCOMM)HmguheterozygoteEarly adult4.18x10-6 
increased total body fat amount2 supporting datasetsMcutm1b(EUCOMM)HmguheterozygoteEarly adult5.32x10-6 
decreased bone mineral content1 supporting datasetMcutm1b(EUCOMM)HmguheterozygoteEarly adult2.82x10-5 
increased fasting circulating glucose level1 supporting datasetMcutm1b(EUCOMM)HmguheterozygoteEarly adult8.82x10-6 
preweaning lethality, complete penetrance1 supporting datasetMcutm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased circulating HDL cholesterol level1 supporting datasetMcutm1b(EUCOMM)HmguheterozygoteEarly adult7.4x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mcutm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Mcutm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Mcutm1c(EUCOMM)HmguWild type floxed exon (post-Flp)mouse
Mcutm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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