Mcu | mitochondrial calcium uniporter
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| increased circulating cholesterol level | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.21x10-5 | ||
| decreased lean body mass | 2 supporting datasets | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.18x10-6 | ||
| increased total body fat amount | 2 supporting datasets | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.32x10-6 | ||
| decreased bone mineral content | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.82x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.82x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.4x10-6 |
| | | | | | | | | | |
External links
No external links available for Mcu.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Mcutm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
| Mcutm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mcutm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | | mouse |
| Mcutm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | es cell |