Mcu | mitochondrial calcium uniporter
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
increased circulating cholesterol level | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.21x10-5 | ||
decreased lean body mass | 2 supporting datasets | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.18x10-6 | ||
increased total body fat amount | 2 supporting datasets | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.32x10-6 | ||
decreased bone mineral content | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.82x10-5 | ||
increased fasting circulating glucose level | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.82x10-6 | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
increased circulating HDL cholesterol level | 1 supporting dataset | Mcutm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.4x10-6 |
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External links
No external links available for Mcu.
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Mcutm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Mcutm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Mcutm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | | mouse |
Mcutm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |