Pfkfb4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

GeneMGI:2687284

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Reproductive system Vision/eye Behavior/neurological Cardiovascular system

18 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

0Associated diseases

Expression examined in:146Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal vocalization	1 supporting dataset	Pfkfb4^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.82x10^-6
eye hemorrhage	1 supporting dataset	Pfkfb4^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.11x10^-7
female infertility	1 supporting dataset	Pfkfb4^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pfkfb4.

Associated images

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Histopathology

There is no histopathology data found for Pfkfb4.

IMPC related publications

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External links

No external links available for Pfkfb4.

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*Pfkfb4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pfkfb4^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pfkfb4^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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