Fbxo10 | F-box protein 10

GeneMGI:2686937Synonyms: FBX10, LOC269529

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Muscle Hematopoietic system Behavior/neurological Cardiovascular system

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:

Life Stage:



abnormal coat/hair pigmentation	3 supporting datasets	Fbxo10^em1(IMPC)J	homozygote	Late adult	1.99x10^-8
abnormal coat/ hair morphology	1 supporting dataset	Fbxo10^em1(IMPC)J	homozygote	Late adult	2.02x10^-5
decreased blood urea nitrogen level	1 supporting dataset	Fbxo10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.2x10^-11
decreased cardiac muscle contractility	2 supporting datasets	Fbxo10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.49x10^-9
decreased mean corpuscular volume	1 supporting dataset	Fbxo10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.76x10^-12
decreased circulating glucose level	1 supporting dataset	Fbxo10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.44x10^-5
decreased neutrophil cell number	2 supporting datasets	Fbxo10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.89x10^-5
decreased circulating calcium level	1 supporting dataset	Fbxo10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.27x10^-8
impaired righting response	1 supporting dataset	Fbxo10^em1(IMPC)J	homozygote	Late adult	1.75x10^-7
decreased circulating phosphate level	1 supporting dataset	Fbxo10^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.92x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbxo10.

Associated images

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Histopathology

There is no histopathology data found for Fbxo10.

IMPC related publications

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External links

No external links available for Fbxo10.

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*Fbxo10^em1(IMPC)J*	Exon Deletion	‌	mouse
*Fbxo10^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Fbxo10^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fbxo10^{tm36009(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Fbxo10^{tm36009(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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