Irgc | immunity related GTPase cinema

GeneMGI:2685948Synonyms: LOC210145, F630044M05Rik, +3 more

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Reproductive system Immune system Nervous system Vision/eye Hematopoietic system Behavior/neurological

11 No significant impact

7 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased prepulse inhibition5 supporting datasetsIrgcem1(IMPC)TcphomozygoteEarly adult3.71x10-10 
persistence of hyaloid vascular system1 supporting datasetIrgcem1(IMPC)TcphomozygoteEarly adult4.04x10-7 
abnormal eye morphology1 supporting datasetIrgcem1(IMPC)TcphomozygoteEarly adultN/A * 
increased monocyte cell number2 supporting datasetsIrgcem1(IMPC)TcphomozygoteEarly adult1.42x10-9 
increased startle reflex1 supporting datasetIrgcem1(IMPC)TcphomozygoteEarly adult5.21x10-5 
male infertility1 supporting datasetIrgcem1(IMPC)TcphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Irgcem1(IMPC)TcpIntra-exon deletionmouse
Irgctm113515(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Irgctm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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