Parp4 | poly (ADP-ribose) polymerase family, member 4

GeneMGI:2685589Synonyms: Adprtl1, VPARP, +5 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Renal/urinary system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal caudal vertebrae morphology	1 supporting dataset	Parp4^em1(IMPC)Mbp	homozygote	Early adult	1.19x10^-6
abnormal vitreous body morphology	1 supporting dataset	Parp4^em1(IMPC)Mbp	homozygote	Early adult	9.09x10^-5
abnormal kidney morphology	1 supporting dataset	Parp4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Parp4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Parp4^em1(IMPC)Mbp	homozygote	Early adult	4.86x10^-5
decreased exploration in new environment	1 supporting dataset	Parp4^em1(IMPC)Mbp	homozygote	Early adult	5.2x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Parp4.

Associated images

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Histopathology

There is no histopathology data found for Parp4.

IMPC related publications

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External links

No external links available for Parp4.

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*Parp4^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Parp4^{tm175182(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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