H1f10 | H1.10 linker histone

GeneMGI:2685307Synonyms: H1X, H1-10, +2 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Nervous system Hematopoietic system Behavior/neurological

13 No significant impact

7 Not tested

Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
46Embryo tissues

Phenotypes

hyperactivity4 supporting datasetsH1f10tm1.1(KOMP)VlcgheterozygoteEarly adult1.33x10-9 
increased fasting circulating glucose level1 supporting datasetH1f10tm1.1(KOMP)VlcghomozygoteEarly adult1.12x10-5 
abnormal brain morphology1 supporting datasetH1f10tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
increased circulating aspartate transaminase level1 supporting datasetH1f10tm1.1(KOMP)VlcgheterozygoteEarly adult6.44x10-7 
increased mean corpuscular hemoglobin1 supporting datasetH1f10tm1.1(KOMP)VlcghomozygoteEarly adult4.39x10-6 
increased circulating free fatty acids level1 supporting datasetH1f10tm1.1(KOMP)VlcgheterozygoteEarly adult7.63x10-5 
increased circulating sodium level1 supporting datasetH1f10tm1.1(KOMP)VlcgheterozygoteEarly adult5.61x10-6 
abnormal spinal cord morphology1 supporting datasetH1f10tm1.1(KOMP)VlcgheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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H1f10tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
H1f10tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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