Asphd1 | aspartate beta-hydroxylase domain containing 1

GeneMGI:2685014Synonyms: A830007L07Rik

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Craniofacial Cardiovascular system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal thymus morphology	1 supporting dataset	Asphd1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Asphd1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal tail morphology	1 supporting dataset	Asphd1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.79x10^-6
abnormal eye morphology	1 supporting dataset	Asphd1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased circulating alkaline phosphatase level	1 supporting dataset	Asphd1^{em1(IMPC)Ccpcz}	homozygote	Early adult	9.7x10^-5
increased circulating creatinine level	1 supporting dataset	Asphd1^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.28x10^-5
abnormal tooth morphology	1 supporting dataset	Asphd1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Asphd1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased heart rate	1 supporting dataset	Asphd1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.13x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Asphd1.

Associated images

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Histopathology

There is no histopathology data found for Asphd1.

IMPC related publications

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External links

No external links available for Asphd1.

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*Asphd1^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Asphd1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Asphd1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Asphd1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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